Plugging Fentanyl Patch Mylan
Even as generic drugmaker Mylan is dealing with a host of other issues, it is recalling more than 100,000 packages of clonazepam, its generic of Klonopin, a drug that is used to treat seizures and panic disorder. According to the most recent FDA Enforcement reports, Mylan actually began the voluntary U.S. Recall of clonazepam in September after discovering the product was out of spec for a known impurity at the 15 and 16 month testing periods. The report indicated they were manufactured at Mylan’s Morgantown, West Virginia, plant. The FDA only posted the recalls for two different strengths in the last week. The company is recalling 1,182 unit dose cards of 300 tablets and 52,618 unit dose blister cards of the 0.5 mg tablets, along with another 46,472 unit dose blister cards of the 1.0 mg tablets. It turns out that at about the same time that Mylan began its recall, Health Canada issued a recall of 1 mg clonazepam tablets manufactured by Canadian company Pharmascience because the lot might also contain tablets of hypertension drug Terazosin-HCl.
Plugging Fentanyl Patch Mylan
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Detailed Fentanyl dosage information for adults and children. -Do not begin a patient on a fentanyl transdermal patch as their first opioid.
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(Revised 5/9/18). It does have a certain whiff of something to it-can't quite ID whether it's someone trying to drive the stock prices up, or what. Got to stick up for myself a bit here. Whilst I may not be the sharpest tool in the shed, if that were my motives, I think I would be scouring investment forums. How will discussing these developments about Australian companies on an american equine forum work at effecting a share price? Anyway, I am happy to leave it at that, and I appreciate the valued responses that were given.
Shin soreness? They were using Oxy for shin soreness? '70% of young thoroughbreds. In training develop cannon bone soreness. The issue is very costly to the industry and for the owners of these expensive horses. $700m annually in lost race fees alone.'
Earlier in the article: ' the shin soreness was rated as either 'moderate' or 'severe' based on Universal Vet lameness scale. Showed no signs of lameness.5 horses pain free in 24 hours following the first patch application. Sixth horse pain free by the second patch application within 48 hours.'
Is it me, or does that sound like a sore horse gets a patch and races on sore but not feelin' it legs the next day? Talk about driving a nail in a wall with a jackhammer. Ie over treating. You don't give PEOPLE oxy for what they would take and get relief from an ibuprofen. Why would you do it for a horse? And what about tolerance?The stars are aligning again.
But that is exactly what I am thinking. Scary thought! I hope they won't ban Aspirin next. We don't need bute at all now. It's hell on some horse's stomachs, and I've known horses who couldn't stay on it longer than two or three days. I recently had a vet suggest bute for long term care of arthritis, and when I mentioned the stomach side effects on my TBs, he said, 'Have you tried previcox?'
I recognize that previcox isn't as cheap as bute, but it is supposed to come without the stomach issues. If we have safe and effective alternatives to bute, why not use them? I'm certainly not suggesting that oxycodone for bucked shins is a good idea; I've never even half way thought of giving a horse an opiate. Use of opiates in horses is very rare, isn't it? There must be some reason that there isn't the horse equivalent of hydrocodone, which is a very common human pain killer. So good to see that the carcinogen phenylbutazone has been banned from use on animals in South Africa.
Even better is the development of topical oxycodone patch that is being developed for pain relief in horses and companion animals. These patches mean the drug does not enter the blood stream. Still awhile away yet, but nice to have a safe effect alternative.The article doesn't state that it is banned from use in South Africa, just that it is banned in horse racing.
And opiods have their own side effects that are far from 'safe'. We don't need bute at all now. It's hell on some horse's stomachs, and I've known horses who couldn't stay on it longer than two or three days. I recently had a vet suggest bute for long term care of arthritis, and when I mentioned the stomach side effects on my TBs, he said, 'Have you tried previcox?' I recognize that previcox isn't as cheap as bute, but it is supposed to come without the stomach issues.
If we have safe and effective alternatives to bute, why not use them? I'm certainly not suggesting that oxycodone for bucked shins is a good idea; I've never even half way thought of giving a horse an opiate. Use of opiates in horses is very rare, isn't it?
There must be some reason that there isn't the horse equivalent of hydrocodone, which is a very common human pain killer.Bute is much more effective for many issues than firocoxib. I use firocoxib when prudent for long term issues, but for some problems it is useless compared to bute; I find that it just isn't as potent of an anti-inflammatory. I tried to use it for my mare's ringbone and gave up because it wasn't helping at all, but a gram of bute a day kept her comfortable. The side effects of bute also tend to be overstated. Its use can lead to gastric ulcers and renal issues (as can firocoxib) which are certainly worthy of caution, but it is not as widespread as some people's hysteria would lead you to believe. Some horses are extremely sensitive and develop colitis with NSAID use and that is certainly an issue, but not a common one in my experience.
We don't need bute at all now. It's hell on some horse's stomachs, and I've known horses who couldn't stay on it longer than two or three days. I recently had a vet suggest bute for long term care of arthritis, and when I mentioned the stomach side effects on my TBs, he said, 'Have you tried previcox?' I recognize that previcox isn't as cheap as bute, but it is supposed to come without the stomach issues.
If we have safe and effective alternatives to bute, why not use them? I'm certainly not suggesting that oxycodone for bucked shins is a good idea; I've never even half way thought of giving a horse an opiate.
Use of opiates in horses is very rare, isn't it? There must be some reason that there isn't the horse equivalent of hydrocodone, which is a very common human pain killer.1) Phenylbutazone is a helluva lot less expensive. 2) Firocoxib is not without GI side effects itself in some animals.
3) Not all horses experience serious side effects from phenylbutazone, even with long-term use. 4) I suspect that firocoxib will have the same issues as bute wrt potential entry to the human food chain, as it is not approved for human use.
Crowne- your interpretation is correct, it is banned on horse racing. I appreciate you clarifying that. Do you think they are banning it as a 'performance enhancing issue' and 'animal safety issue' (i.e. Racing with some type of pain inhibitor) or for the potential long term effects on the health of the horse?
Truth is there really isn't a totally 'safe' drug. Whilst each has it's effect they also have it's side effects. The question I suppose under discussion is what risk is acceptable to warrant the effect.
After a back injury I was prescribed fentanyl patches. Holy Hannah, I was high as a kite (and sick as a dog). I don't understand how it can be delivered by a patch but not be systemic but I'm not in that business. Really, as above, what could possibly go wrong? Wow, Fentanyl patches are designed only for around the clock pain relief in previously opioid tolerant individuals. I am on 75mcg per hour, and the patch comes in one of two ways.
Duragesic brand is an actual patch pouch with a gel medication in it that absorbs through the sticky side into your skin over 72 hours. These are the easiest to abuse, as you simply cut it open and squirt out the medication inside.
More than one drug abuser has died from Fentanyl overdose as it is extremely hard to be accurate this way. The second type manufactured by Mylan Pharmaceuticals among others is a patch more like the nicotine patch that is just a plastic patch with the drug actually in the matrix of the patch. Still absorbs into your skin over 72 hours, but MUCH harder to abuse as you cannot easily extract the drug. I said not easy, not 'impossible.' People still cut them into small pieces and either soak the patch bit in some sort of substrate to draw the drug out of the matrix, or they simply fold the plastic and put it drug side out into the space between the gum and the teeth where it will absorb rapidly and cause a high. Worn correctly, Fentanyl patches don't typically cause a 'high' as they are something your body learns to tolerate.
Abused, it is supposed to be a very good high, however incredibly dangerous it is to try and get high but not dead. However abusers will do anything for a fix I am told. I personally don't understand wanting to put these in my body for any reason other than absolute necessity as the side effects SUCK. Gumshoe, if you were not previously opioid tolerant, I am shocked you were prescribed a Fentanyl patch for that. They are absolutely systemic, and I cannot imagine the US approving an Oxy patch for use in horses or people as it would just be one more way for the wrong kind of user to obtain a very powerful drug for getting high. The new Oxy pills at least have something in them that makes them pretty impervious to crushing or splitting so it is somewhat harder to abuse them via IV or plugging. Still easy to buy off the street and just eat them the old fashioned way.
Unfortunately they say these patches are harder than heroin to get off of. So even though I have asked them to start tapering me down, the same doc that prescribed them to me all these months doesn't want to do the step down process he is making me go see a completely different doctor to get off them. If I had known then what I know now. Crowne- your interpretation is correct, it is banned on horse racing.
I appreciate you clarifying that. Do you think they are banning it as a 'performance enhancing issue' and 'animal safety issue' (i.e.
Racing with some type of pain inhibitor) or for the potential long term effects on the health of the horse? Truth is there really isn't a totally 'safe' drug. Whilst each has it's effect they also have it's side effects.
The question I suppose under discussion is what risk is acceptable to warrant the effect.The question is weighing the risks and benefits. As someone else astutely noted, better the devil you know Bute, Previcox than the devil you do not Oxy patches.
But beyond the idea that we already have drugs that work well that we already use and 'know'. The problem with opiode abuse in this country is horrendous. Kids are dropping like flies in my small, rural community from heroine. Adding an Oxy patch to the arsenal that horseman use? Not a risk worth taking, considering the alternatives we already have that do not have the risk of drug seekers. Then there's the idea that you're over treating.
The study itself is really mind boggling on many levels- the injury that they treated, their measures for 'benefit'.sigh. We have things that work, and they work well, we don't need an atomic bomb to get rid of mosquitos.